Week 2 quiz review - Lecture notes week 2 Advanced Pharmacology (Chamberlain College of Nursing).
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Week 2 quiz review - Lecture notes week 2 Advanced Pharmacology (Chamberlain College of Nursing) Week 2 Study Guide Chapter 22: Drugs Affecting the Reproductive System Androgens and Antiandrog ens: uses, effects, side effects and monitoring Androgens: Hormones that primarily influence growth and development of male productive system; predominantly testosterone produced in male testes Function of androgens: Growth, mauration & maintenance of male sex organs; skeletal growth spurt/fusion of epipyseal growth plate; sebacious gland activation; enhance production eythroproeitic stimlulating factors; causes baldness, pubic hair & acne, playing a role in libido How androgens used to tx male disorders: Hypogonadism (failure of testes) How androgens used to tx female disorders: Endometriososis, libido,post menapausal symptoms How androgens used to tx both sexes: Cancer, hiv, athletic enchancement, increase muscle mass Androgen clinical monitoring: Goal to tx abnormal testosterone levels, Check serum testosterone, lipids,liver function,CBC, PSA and digital prostate exams in men Hepatic toxicity:liver function test q 6 months Androgen contraindications: Male breast/prostate CA, pregnant/lactation How androgens prescribed: A controlled substance, requires dea #; comes in injectables,transdermal,oral and gel Injectable androgens/testosterone: Proportionate:short acting, q2-3 D, Cypionate: long acting,q 2-3wks, Enanthate: long acting,q 2-3 wks Transdermal androgen/testosterone: Fluoxymesterone: oral,short acting, up to 4xday, Methyltestosterone: oral,buccal,short acting,daily Androgen ADR: Prostatic hypertrophy, Sleep apnea, Acne/baldness, Female virilization,menstrual irregularities, Male gymecomastia,reduced, Sperm,ha,dprsn,decreased, libido/fertility, Hepatic neoplasm,hepatitis,jaundice Androgen Rx considerations: IM vs PO vs TD, Aqueous vs oil IM: oils last longer Examples of androgen hormone inhibitors: AKA: 5a reductase inhibitors, Finasteride (proscar,propecia), Dutasteride (avodart) Types of antiandrogens: Androgen hormone inhibitors, Gonadotropin releasing hormone analogue, Direct antiandrogens, Aldosterone antagonist & 5a reductase inhibitor Dosing for finasteride: 5mg for BPH, 1mg for male pattern baldness Examples of Gonadotropin releasing hormone analogues: AKA luteinizing hormone-releasing hormone agonist, Leuprolide acetate (lupron) Luteinizing hormones function: Stimulate ovaries to release eggs Gonadotropin releasing hormone analogues: Create reversible chemical orchiectomy state in males (blocks testosterone production) & oophorectomy state in females; tx advanced prostate CA in males & management of endometriosis, uterine fibroids in females & POS BOOK: Adverse Drug Reactions The androgens as a class are potent agents and can have serious or even fatal reactions if used improperly. When properly used, androgens mimic the body’s endogenous processes. However, prolonged use of high doses of androgens has been associated with the development of potentially life-threatening hepatitis, hepatic neoplasms, cholestatic hepatitis, jaundice, and hepatocellular carcinoma. Cholestatic hepatitis and jaundice occur at relatively low doses of fluoxymesterone and methyltestosterone. These conditions are reversible with drug discontinuance. Gender-specific side effects have been reported with the use of androgen therapy. Men may develop gynecomastia and reduced sperm levels that threaten fertility. Acne and baldness may occur, even with short- term therapy. Men can paradoxically have decreased libido, depression, and headache with exogenous administration of